α,α1-联吡啶对脑内去甲肾上腺素、多巴胺和5-羟色胺水平以及多巴胺-β-羟化酶活性的影响。
The effect of alpha, alpha1-dipyridyl on noradrenaline, dopamine and 5-hydroxytryptamine levels and on dopamine-beta-hydroxylase activity in brain.
作者信息
Mogilnicka E, Szmigielski A, Niewiadomska A
出版信息
Pol J Pharmacol Pharm. 1975 Nov-Dec;27(6):619-24.
PMID:1715
Abstract
The effects of alpha, alpha1-dipyridyl (DP) on noradrenaline (NA), dopamine (DA) and 5-hydroxytryptamine (5-HT) levels in rat and mouse brain and on dopamine-beta-hydroxylase (DbetaH) activity in rat brain have been studied, DP decreases NA level and inhibits DbetaH activity in a dose dependent manner, without affecting DA or 5-HT levels.
摘要
已研究了α,α1-联吡啶（DP）对大鼠和小鼠脑内去甲肾上腺素（NA）、多巴胺（DA）和5-羟色胺（5-HT）水平以及对大鼠脑内多巴胺-β-羟化酶（DβH）活性的影响。DP可降低NA水平，并以剂量依赖方式抑制DβH活性，而不影响DA或5-HT水平。
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