Hanneman S K
University of Texas Health Science Center at Houston, Center for Nursing Research, 77030, USA.
Biol Res Nurs. 2001 Apr;2(4):236-48. doi: 10.1177/109980040100200403.
Experimental control and mathematical techniques increase confidence that results of circadian temperature rhythm studies reflect true changes in the circadian timing system versus coupling with exogenous synchronizers. Masking effects represent confounding influences in studies that are concerned with the endogenous temperature rhythm. Because it is technically difficult to measure directly the behavior of the endogenous timing system, marker rhythms are used as proxy measures. However in addition to entraining, the external environment exerts a direct masking effect on the monitored rhythm. Methods for measuring circadian temperature rhythm are reviewed in this article. Constant routine, forced desynchrony, and purification methods represent attempts, at an experimental or mathematical level, to remove masking effects and more accurately capture the endogenous circadian temperature rhythm. Exogenous factors have not been subjected to the same scrutiny as the endogenous features of circadian temperature rhythm. But it is the environmental context, the extent to which the endogenous features are adaptively modified by the field environment, that will ultimately determine the biological value of circadian temperature rhythm to the organism. Thus, nurse investigators are encouraged to use rigorous methods to study both endogenous circadian temperature rhythm and exogenous rhythms.
实验控制和数学技术增强了人们的信心，即昼夜节律温度研究的结果反映了昼夜节律系统的真实变化，而非与外源性同步器的耦合。掩盖效应在关注内源性温度节律的研究中代表着混杂影响。由于直接测量内源性计时系统的行为在技术上存在困难，标记节律被用作替代测量方法。然而，除了同步作用外，外部环境对监测到的节律还会产生直接的掩盖效应。本文对测量昼夜节律温度的方法进行了综述。持续常规法、强制去同步法和纯化法代表了在实验或数学层面上试图消除掩盖效应并更准确地捕捉内源性昼夜节律温度的尝试。外源性因素尚未像昼夜节律温度的内源性特征那样受到同等程度的审视。但正是环境背景，即内源性特征被野外环境适应性改变的程度，最终将决定昼夜节律温度对生物体的生物学价值。因此，鼓励护理研究人员采用严谨的方法来研究内源性昼夜节律温度和外源性节律。
