利福霉素和泰勒霉素衍生物对小鼠Friend病毒白血病的影响。

Effect of rifamycin and tilorone derivatives on Friend virus leukemia in mice.

作者信息

Rana M W, Pinkerton H, Rankin A

出版信息

Proc Soc Exp Biol Med. 1975 Oct;150(1):32-5. doi: 10.3181/00379727-150-38968.

Abstract

Several derivatives of rifamycin, and analogs of the tilorone-fluoranthene group were tested for inhibition of splenic enlargement in Friend virus leukemia. At least three members of the rifamycin group caused significant inhibition (31-49%) as did at least three members of the tilorone group (32-48%). These six compounds are among those found by others (6, 7) to be most inhibitory in vitro to the RNA-directed DNA polymerase of oncornaviruses. However our studies do not furnish direct evidence for or against a role of inhibition of the viral enzyme in the suppression of splenomegaly. None of the agents was as effective as methotrexate, which caused 90-92% inhibition. The activity of five of the agents was reduced, rather than enhanced by the injection of adjuvants (M. butyricum and pertussis vaccine). Three of the agents had a subtractive, rather than an additive effect on the inhibition caused by methotrexate alone.

摘要

对利福霉素的几种衍生物以及泰勒霉素-荧蒽类的类似物进行了测试，以观察它们对弗氏病毒白血病脾脏肿大的抑制作用。利福霉素组中至少有三种成员引起了显著抑制（31%-49%），泰勒霉素组中至少有三种成员也如此（32%-48%）。这六种化合物是其他人（6, 7）发现的在体外对肿瘤病毒的RNA指导的DNA聚合酶抑制作用最强的化合物。然而，我们的研究并未提供支持或反对抑制病毒酶在脾肿大抑制中作用的直接证据。没有一种药物的效果与甲氨蝶呤一样好，甲氨蝶呤可引起90%-92%的抑制。注射佐剂（丁酸分枝杆菌和百日咳疫苗）会降低而不是增强其中五种药物的活性。其中三种药物对甲氨蝶呤单独引起的抑制作用具有减效而非增效作用。