Vargin V V, Zschiesche W, Semenov B F
Acta Virol. 1977 Mar;21(2):114-8.
The effect of tilorone hydrochloride on experimental infections of mice with West Nile, Langat and Dengue type 2 viruses were studied. The drug significantly reduced the mortality after intraperitoneal inoculation of West Nile virus, but failed to affect intracerebral infection with Langat or Dengue viruses. Tilorone partially reversed cyclophosphan-enhanced mortality after extraneural inoculation of West Nile and Langat viruses. The possible modes of action of tilorone, interferon-inducing ability and stimulation of humoral immunity, are discussed.
研究了盐酸替洛隆对小鼠感染西尼罗河病毒、兰加特病毒和登革2型病毒的实验性感染的影响。该药物在腹腔接种西尼罗河病毒后显著降低了死亡率，但对兰加特病毒或登革病毒的脑内感染没有影响。在经神经外接种西尼罗河病毒和兰加特病毒后，替洛隆部分逆转了环磷酰胺增强的死亡率。讨论了替洛隆可能的作用方式、诱导干扰素的能力和对体液免疫的刺激。
