Seidel H J, Opitz U, Kreja L
Cancer Chemother Pharmacol. 1980;5(1):49-54. doi: 10.1007/BF00578562.
Hematological effects of tilorone, an interferon inducer, on the hematopoietic cell system of normal CBA/Ca mice and on the development of Friend virus (FV-P)-induced polycythemia in DBA/2 mice were studied. In normal mice 80 mg/kg IP had a marked depressive effect on pluripotent (CFU-s), granuloid committed (CFU-C), and erythroid committed (CFU-E) stem cells with regeneration between days 5 and 12. In bone marrow smears only lymphopenia was detected. Treatment of mice before FV-P infection caused a slight retardation in the development of the splenomegaly and the transformation of bone marrow cells to Ep independence. Repeated treatment after FV-P infection also reduced the increase in spleen weight and the development of reticulocytosis, but the Ep independence of bone marrow and spleen cells was not influenced. In vitro exposure of normal cells and cells from FV-P-infected animals to the drug showed the same sensitivity of colony growth in normal as well as in Ep-independent CFU-E. The action of the drug on Friend leukemia is at least in part considered a toxic effect on the hematopoietic stem cell system.
研究了干扰素诱导剂泰洛龙对正常CBA/Ca小鼠造血细胞系统以及对DBA/2小鼠中Friend病毒（FV-P）诱导的红细胞增多症发展的血液学影响。在正常小鼠中，腹腔注射80mg/kg对多能（CFU-s）、粒系定向（CFU-C）和红系定向（CFU-E）干细胞有显著抑制作用，在第5至12天之间再生。在骨髓涂片中仅检测到淋巴细胞减少。在FV-P感染前对小鼠进行治疗会使脾肿大的发展和骨髓细胞向红细胞生成素非依赖性的转化略有延迟。FV-P感染后重复治疗也会减少脾脏重量的增加和网织红细胞增多症的发展，但骨髓和脾细胞的红细胞生成素非依赖性不受影响。正常细胞和FV-P感染动物的细胞在体外暴露于该药物时，显示出正常和红细胞生成素非依赖性CFU-E中集落生长的相同敏感性。该药物对Friend白血病的作用至少部分被认为是对造血干细胞系统的毒性作用。
