Popa Eliane R, Stegeman Coen A, Kallenberg Cees G M, Tervaert Jan Willem Cohen
Department of Clinical Immunology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Arthritis Res. 2002;4(2):77-9. doi: 10.1186/ar392. Epub 2001 Oct 26.
Wegener's granulomatosis (WG) is a form of systemic vasculitis. It is characterized by granulomatous inflammation in the upper and lower airways, vasculitis and necrotizing glomerulonephritis, and is strongly associated with antineutrophil cytoplasmic antibodies against proteinase 3. Since the etiology of the disease is not clear, treatment, consisting of corticosteroids and immunosuppressives, is nonspecific and associated with severe side effects. Pinpointing the trigger(s) of the disease would highly improve treatment. Clinical evidence shows that an infectious agent, the bacterium Staphylococcus aureus, is a risk factor for disease relapse, suggesting its involvement in the pathogenesis of WG. Here we review both clinical and experimental data that either indicate or support a role for S. aureus in WG.
韦格纳肉芽肿（WG）是一种系统性血管炎。其特征为上、下呼吸道的肉芽肿性炎症、血管炎和坏死性肾小球肾炎，且与抗蛋白酶3的抗中性粒细胞胞浆抗体密切相关。由于该病病因不明，由皮质类固醇和免疫抑制剂组成的治疗方法缺乏特异性且伴有严重副作用。明确疾病的触发因素将极大地改善治疗效果。临床证据表明，一种病原体——金黄色葡萄球菌是疾病复发的危险因素，提示其参与了韦格纳肉芽肿的发病机制。在此，我们综述了表明或支持金黄色葡萄球菌在韦格纳肉芽肿中起作用的临床和实验数据。
