Gasco Milena, Shami Shukri, Crook Tim
Department of Surgery, Oldchurch Hospital, Romford, UK.
Breast Cancer Res. 2002;4(2):70-6. doi: 10.1186/bcr426. Epub 2002 Feb 12.
p53 mutation remains the most common genetic change identified in human neoplasia. In breast cancer, p53 mutation is associated with more aggressive disease and worse overall survival. The frequency of mutation in p53 is, however, lower in breast cancer than in other solid tumours. Changes, both genetic and epigenetic, have been identified in regulators of p53 activity and in some downstream transcriptional targets of p53 in breast cancers that express wild-type p53. Molecular pathological analysis of the structure and expression of constituents of the p53 pathway is likely to have value in diagnosis, in prognostic assessment and, ultimately, in treatment of breast cancer.
p53突变仍然是人类肿瘤中最常见的基因改变。在乳腺癌中，p53突变与更具侵袭性的疾病和更差的总生存率相关。然而，p53的突变频率在乳腺癌中低于其他实体瘤。在表达野生型p53的乳腺癌中，已在p53活性调节因子和p53的一些下游转录靶点中发现了基因和表观遗传变化。对p53通路成分的结构和表达进行分子病理分析可能在乳腺癌的诊断、预后评估以及最终治疗中具有价值。
