来自东亚国家的结核分枝杆菌北京家族分离株的rpoB基因型
rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries.
作者信息
Qian Lishi, Abe Chiyoji, Lin Tao-Ping, Yu Ming-Chih, Cho Sang-Nae, Wang Sumin, Douglas James T
机构信息
Department of Microbiology, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
出版信息
J Clin Microbiol. 2002 Mar;40(3):1091-4. doi: 10.1128/JCM.40.3.1091-1094.2002.
Abstract
The 81-bp region of the rpoB gene in 66 Rif(r) Mycobacterium tuberculosis isolates from China, Japan, Korea, and Taiwan was analyzed. Twelve single-nucleotide substitutions in the rpoB gene were detected. The most prevalent mutations were at Ser-531 (52%), Asp-516 (17%), and His-526 (11%). Mutations were not found in seven (11%) of the isolates. Higher mutation rates in 50 Beijing family isolates were found than in other isolates for mutations at Asp-516 (18 and 12.5%, respectively) and His-526 (12 and 6.3%, respectively). The different rates of mutation may reflect the choice of rifamycin analogs.
摘要
对来自中国、日本、韩国和台湾地区的66株耐利福平结核分枝杆菌分离株的rpoB基因81bp区域进行了分析。在rpoB基因中检测到12个单核苷酸替换。最常见的突变位于Ser-531（52%）、Asp-516（17%）和His-526（11%）。在7株（11%）分离株中未发现突变。50株北京家族分离株在Asp-516（分别为18%和12.5%）和His-526（分别为12%和6.3%）位点的突变率高于其他分离株。不同的突变率可能反映了利福霉素类似物的选择。
相似文献
1
rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries.来自东亚国家的结核分枝杆菌北京家族分离株的rpoB基因型
J Clin Microbiol. 2002 Mar;40(3):1091-4. doi: 10.1128/JCM.40.3.1091-1094.2002.
2
Rifampin-resistance-associated mutations in the rifampin-resistance-determining region of the gene of clinical isolates in Shanghai, PR China.中国上海临床分离株中 基因的利福平耐药决定区的利福平耐药相关突变。
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001317. Epub 2021 Jan 28.
3
Molecular characteristics of rifampin and isoniazid resistant Mycobacterium tuberculosis strains from Beijing, China.来自中国北京的耐利福平及异烟肼结核分枝杆菌菌株的分子特征
Chin Med J (Engl). 2007 May 5;120(9):814-9.
4
[Characterization of rpoB mutation in rifampin - resistant clinical Mycobacterium tuberculosis isolates from China].[中国耐利福平临床结核分枝杆菌分离株中rpoB基因突变的特征分析]
Zhonghua Jie He He Hu Xi Za Zhi. 2001 Apr;24(4):231-5.
5
Characterization of rpoB mutations in rifampicin-resistant Mycobacterium tuberculosis isolated in China.中国分离的耐利福平结核分枝杆菌中rpoB基因突变特征分析
Tuberculosis (Edinb). 2002;82(2-3):79-83. doi: 10.1054/tube.2002.0326.
6
Characterization of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Kuwait and Dubai.科威特和迪拜耐利福平临床结核分枝杆菌分离株中rpoB基因突变的特征分析
Diagn Microbiol Infect Dis. 2002 Nov;44(3):245-52. doi: 10.1016/s0732-8893(02)00457-1.
7
Rifampicin resistance mutations in the 81 bp RRDR of rpoB gene in Mycobacterium tuberculosis clinical isolates using Xpert MTB/RIF in Khyber Pakhtunkhwa, Pakistan: a retrospective study.在巴基斯坦开伯尔-普赫图赫瓦省使用Xpert MTB/RIF检测结核分枝杆菌临床分离株rpoB基因81bp利福平耐药决定区的利福平耐药突变：一项回顾性研究
BMC Infect Dis. 2016 Aug 12;16:413. doi: 10.1186/s12879-016-1745-2.
8
9
Mutations in the rpoB gene of rifampin-resistant Mycobacterium tuberculosis strains isolated mostly in Asian countries and their rapid detection by line probe assay.主要在亚洲国家分离出的耐利福平结核分枝杆菌菌株rpoB基因的突变及其通过线性探针分析的快速检测
J Clin Microbiol. 1999 Aug;37(8):2663-6. doi: 10.1128/JCM.37.8.2663-2666.1999.
10
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis.利用变性梯度凝胶电泳检测结核分枝杆菌中与利福平耐药相关的rpoB基因突变
Antimicrob Agents Chemother. 2005 Jun;49(6):2200-9. doi: 10.1128/AAC.49.6.2200-2209.2005.
引用本文的文献
1
Epidemiological changes in tuberculosis and genotyping characteristics of in Ningxia, China.中国宁夏结核病的流行病学变化及基因分型特征
Front Microbiol. 2025 Jun 4;16:1582163. doi: 10.3389/fmicb.2025.1582163. eCollection 2025.
2
Mutations associated with resistance to rifampicin and isoniazid identified in strains of the complex by GenoType MTBDRplus in Panama, 2015-2021.2015年至2021年在巴拿马通过GenoType MTBDRplus在该复合体菌株中鉴定出的与利福平及异烟肼耐药相关的突变。
Microbiol Spectr. 2025 Jul;13(7):e0240024. doi: 10.1128/spectrum.02400-24. Epub 2025 Jun 9.
3
Prevalence of Beijing Central Asian/Russian Cluster 94-32 among Multidrug-Resistant in Kazakhstan.哈萨克斯坦耐多药结核病患者中北京中亚/俄罗斯94-32簇的流行情况。
Antibiotics (Basel). 2023 Dec 20;13(1):9. doi: 10.3390/antibiotics13010009.
4
The impact of work interference with family on depressive symptoms among married working women: A longitudinal panel study.工作与家庭干扰对已婚职业女性抑郁症状的影响：一项纵向面板研究。
PLoS One. 2022 Nov 9;17(11):e0276230. doi: 10.1371/journal.pone.0276230. eCollection 2022.
5
Comparison on Major Gene Mutations Related to Rifampicin and Isoniazid Resistance between Beijing and Non-Beijing Strains of : A Systematic Review and Bayesian Meta-Analysis.贝叶斯荟萃分析：比较利福平及异烟肼耐药相关主要基因突变在中国北京株和非北京株之间的差异：一项系统综述。
Genes (Basel). 2022 Oct 13;13(10):1849. doi: 10.3390/genes13101849.
6
Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis.跨损伤聚合酶 DinB1 和 DnaE2 通过取代和移码突变在分枝杆菌基因组多样化中的独特作用。
Nat Commun. 2022 Aug 2;13(1):4493. doi: 10.1038/s41467-022-32022-8.
7
Novel mutations detected from drug resistant Mycobacterium tuberculosis isolated from North East of Thailand.从泰国东北部分离出的耐多药结核分枝杆菌中检测到的新突变。
World J Microbiol Biotechnol. 2021 Oct 13;37(11):194. doi: 10.1007/s11274-021-03163-7.
8
Low-Level Rifampin Resistance and Mutations in Mycobacterium tuberculosis: an Analysis of Whole-Genome Sequencing and Drug Susceptibility Test Data in New York.结核分枝杆菌低水平利福平耐药与突变：纽约全基因组测序与药物敏感性试验数据的分析。
J Clin Microbiol. 2021 Mar 19;59(4). doi: 10.1128/JCM.01885-20.
9
Distribution and Frequency of B Mutations Detected by Xpert MTB/RIF Assay Among Beijing and Non-Beijing Rifampicin Resistant Isolates in Bangladesh.在孟加拉国北京型和非北京型利福平耐药菌株中，采用Xpert MTB/RIF检测法检测到的B基因突变的分布及频率
Infect Drug Resist. 2020 Mar 10;13:789-797. doi: 10.2147/IDR.S240408. eCollection 2020.
10
Investigation of the Mutations Causing Rifampin Resistance by Rapid Screening in in North-East of Iran.伊朗东北部通过快速筛查对导致利福平耐药的突变进行调查。
Iran J Pathol. 2018 Fall;13(4):429-437. Epub 2018 Sep 25.
本文引用的文献
1
Spread of drug-resistant pulmonary tuberculosis in Estonia.耐药性肺结核在爱沙尼亚的传播。
J Clin Microbiol. 2001 Sep;39(9):3339-45. doi: 10.1128/JCM.39.9.3339-3345.2001.
2
Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis clinical isolates from India.来自印度的耐多药结核分枝杆菌临床分离株rpoB基因的突变
J Clin Microbiol. 2001 Aug;39(8):2987-90. doi: 10.1128/JCM.39.8.2987-2990.2001.
3
Global trends in resistance to antituberculosis drugs. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance.抗结核药物耐药性的全球趋势。世界卫生组织-国际防痨和肺部疾病联盟抗结核药物耐药性监测工作组
N Engl J Med. 2001 Apr 26;344(17):1294-303. doi: 10.1056/NEJM200104263441706.
4
rpoB mutations as an epidemiologic marker in rifampin-resistant Mycobacterium tuberculosis.rpoB基因突变作为耐利福平结核分枝杆菌的流行病学标志物
Int J Tuberc Lung Dis. 2000 Aug;4(8):765-70.
5
Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from Brazil.来自巴西的耐多药结核分枝杆菌分离株rpoB基因的突变
J Clin Microbiol. 2000 Aug;38(8):3119-22. doi: 10.1128/JCM.38.8.3119-3122.2000.
6
Criteria for the control of drug-resistant tuberculosis.耐多药结核病控制标准。
Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8180-5. doi: 10.1073/pnas.140102797.
7
Mycobacterium tuberculosis Beijing genotype emerging in Vietnam.结核分枝杆菌北京基因型在越南出现。
Emerg Infect Dis. 2000 May-Jun;6(3):302-5. doi: 10.3201/eid0603.000312.
8
Molecular analysis of rifampin and isoniazid resistance of Mycobacterium tuberculosis clinical isolates in Seville, Spain.西班牙塞维利亚结核分枝杆菌临床分离株对利福平和异烟肼耐药性的分子分析。
Tuber Lung Dis. 1999;79(3):187-90. doi: 10.1054/tuld.1998.0195.
9
Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.结核分枝杆菌抗微生物剂耐药性的分子遗传学基础：1998年更新版
Tuber Lung Dis. 1998;79(1):3-29. doi: 10.1054/tuld.1998.0002.
10
Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project.共识声明。全球结核病负担：按国家估算的发病率、患病率和死亡率。世卫组织全球监测项目。
JAMA. 1999 Aug 18;282(7):677-86. doi: 10.1001/jama.282.7.677.
Zotero 插件