Wein Francine B, Levin Leonard A
Department of Ophthalmology, McGill University Health Center, Montreal, Canada.
Curr Opin Ophthalmol. 2002 Apr;13(2):61-7. doi: 10.1097/00055735-200204000-00002.
The most common optic neuropathy is glaucomatous optic neuropathy, distinguished by a distinctive and progressive excavation of the optic nerve head without significant pallor of the remaining neuroretinal rim. Neuroprotection is a novel strategy for treating disorders that affect the nervous system by preventing death of neurons. In glaucomatous optic neuropathy, the neurons that die are retinal ganglion cells. This article reviews the recent basic science relevant to neuroprotection, particularly with respect to retinal ganglion cell death in glaucomatous and other optic neuropathies.
最常见的视神经病变是青光眼性视神经病变，其特征是视神经乳头有独特的进行性凹陷，而其余神经视网膜边缘无明显苍白。神经保护是一种通过防止神经元死亡来治疗影响神经系统疾病的新策略。在青光眼性视神经病变中，死亡的神经元是视网膜神经节细胞。本文综述了与神经保护相关的最新基础科学，特别是关于青光眼性和其他视神经病变中视网膜神经节细胞死亡的研究。
