Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
J Cell Mol Med. 2021 Nov;25(22):10349-10361. doi: 10.1111/jcmm.16996. Epub 2021 Oct 26.
Circular RNAs (circRNAs) are a novel group of endogenous RNAs with a circular structure. Growing evidence indicates that circRNAs are involved in a variety of human diseases including malignancies. CircRNA ZNF609 (circ-ZNF609), derived from the ZNF609 gene sequence, has been demonstrated to be involved in the development and progression of many diseases. circ-ZNF609 is thought to be a viable diagnostic and prognostic biomarker for several diseases and might be a new therapeutic target, but further research is needed to accelerate clinical application. Here, we review the biogenesis and function of circRNAs and the functional roles and molecular mechanism related to circ-ZNF609 in neoplasms and other diseases.
环状 RNA（circRNAs）是一类具有环状结构的新型内源性 RNA。越来越多的证据表明，circRNAs 参与了多种人类疾病，包括恶性肿瘤。circRNA ZNF609（circ-ZNF609）来源于 ZNF609 基因序列，已被证明参与了许多疾病的发生和发展。circ-ZNF609 被认为是几种疾病有前途的诊断和预后生物标志物，可能成为新的治疗靶点，但需要进一步的研究来加速其临床应用。在这里，我们综述了 circRNAs 的生物发生和功能，以及 circ-ZNF609 在肿瘤和其他疾病中的功能作用和分子机制。
