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先天性和后天性儿童脑积水的神经心理学研究结果

Neuropsychological findings in congenital and acquired childhood hydrocephalus.

作者信息

Mataró M, Junqué C, Poca M A, Sahuquillo J

机构信息

Department of Psychiatry and Clinical Psychobiology, Faculty of Psychology, University of Barcelona, Spain.

出版信息

Neuropsychol Rev. 2001 Dec;11(4):169-78. doi: 10.1023/a:1012904907249.

Abstract

Hydrocephalus is an increase in cerebrospinal fluid volume that can be caused by a variety of etiologies. The most common connatal and acquired causes of hydrocephalus are spina bifida, aqueduct stenosis, and preterm low birthweight infants with ventricular hemorrhage. In general, the literature suggests mild neuropsychological deficits associated with hydrocephalus, which are predominant in visuospatial and motor functions, and other nonlanguage skills. Although the precise nature of the neuropsychological deficits in hydrocephalus are not completely known, several factors such as etiology, raised intracranial pressure, ventricular size, and changes in gray and white matter tissue composition as well as shunt treatment complications have been shown to influence cognition. In fact, the presence of complications and other brain abnormalities in addition to hydrocephalus such as infections, trauma, intraventricular hemorrhage, low birthweight, and asphyxia are important determinants of the ultimate cognitive status, placing the child at a high risk of cognitive impairment.

摘要

脑积水是指脑脊液量增加,可由多种病因引起。脑积水最常见的先天性和后天性病因是脊柱裂、导水管狭窄以及患有脑室出血的早产低体重儿。一般来说,文献表明脑积水与轻度神经心理缺陷有关,这些缺陷主要表现在视觉空间和运动功能以及其他非语言技能方面。虽然脑积水所致神经心理缺陷的确切性质尚不完全清楚,但已表明病因、颅内压升高、脑室大小、灰质和白质组织成分变化以及分流治疗并发症等多种因素会影响认知。事实上,除脑积水外还存在并发症和其他脑部异常情况,如感染、创伤、脑室内出血、低体重和窒息等,这些都是最终认知状态的重要决定因素,使儿童面临认知障碍的高风险。

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