Madrid Cristina, Nieto José M, Juárez Antonio
Departament de Microbiologia, Universitat de Barcelona, Spain.
Int J Med Microbiol. 2002 Feb;291(6-7):425-32. doi: 10.1078/1438-4221-00149.
Virulent bacteria are able to sense temperature changes and respond by modifying the expression of--among others--genes that code for virulence factors. The chromatin-associated protein H-NS has been shown to play a role in the thermomodulation of virulence factor expression. In addition to H-NS, proteins of the Hha/YmoA family have also been identified in different enterobacteria as participating in the thermoregulation of some virulence factors. For one of these proteins, the Hha protein, it has been shown that it interacts with H-NS, and both proteins form a nucleoid-protein complex responsible for the thermoregulation of, at least, E. coli hemolysin. The presence of genes coding for homologues of both proteins on some conjugative plasmids and their relation to thermoregulation suggests that this complex could also play a role in the regulation of plasmid transfer.
致病细菌能够感知温度变化，并通过改变（包括但不限于）编码毒力因子的基因表达来做出反应。已证明与染色质相关的蛋白质H-NS在毒力因子表达的温度调节中发挥作用。除了H-NS，Hha/YmoA家族的蛋白质也已在不同的肠道细菌中被鉴定出参与某些毒力因子的温度调节。对于其中一种蛋白质Hha蛋白，已证明它与H-NS相互作用，并且这两种蛋白质形成一种类核蛋白复合物，至少负责大肠杆菌溶血素的温度调节。一些接合质粒上存在编码这两种蛋白质同源物的基因以及它们与温度调节的关系表明，这种复合物也可能在质粒转移的调节中发挥作用。
