Department of Epizootiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, 10-718 Olsztyn, Poland.
Toxins (Basel). 2022 Feb 5;14(2):118. doi: 10.3390/toxins14020118.
, an etiological agent of yersiniosis, is a bacterium whose pathogenicity is determined, among other things, by its ability to produce toxins. The aim of this article was to present the most important toxins that are produced by biotype 1A strains of , and to discuss their role in the pathogenesis of yersiniosis. biotype 1A strains are able to synthesize variants of thermostable YST enterotoxin and play a key role in the pathogenesis of yersiniosis. Biotype 1A strains of also produce pore-forming toxins, YaxA and YaxB. These toxins form pores in the cell membrane of host target cells and cause osmotic lysis, which is of particular importance in systemic infections. Insecticidal toxin complex genes have been detected in some clinical biotype 1A strains of . However, their role has not yet been fully elucidated. Strains belonging to biotype 1A have long been considered non-pathogenic. This view is beginning to change due to the emerging knowledge about the toxigenic potential of these bacteria and their ability to overcome the defense barriers of the host organism.
耶尔森菌是耶尔森氏菌病的病因，是一种细菌，其致病性除其他外取决于其产生毒素的能力。本文旨在介绍 1A 生物型产生的最重要的毒素，并讨论它们在耶尔森氏菌病发病机制中的作用。1A 生物型菌株能够合成耐热 YST 肠毒素的变体，在耶尔森氏菌病发病机制中发挥关键作用。1A 生物型的耶尔森氏菌还产生 孔形成毒素 YaxA 和 YaxB。这些毒素在宿主靶细胞的细胞膜上形成孔，导致渗透裂解，这在全身性感染中尤为重要。一些临床 1A 生物型菌株中检测到杀虫毒素复合物基因。然而，它们的作用尚未完全阐明。属于 1A 生物型的菌株长期以来被认为是无致病性的。由于对这些细菌的毒力潜力及其克服宿主生物体防御屏障的能力的新知识的出现，这种观点开始发生变化。
