Armstrong William B, Neev Joseph A, Da Silva Luiz B, Rubenchik Alexander M, Stuart Brent C
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, CA 92868, USA.
Lasers Surg Med. 2002;30(3):216-20. doi: 10.1002/lsm.10034.
The purpose of this study was to evaluate the ablation of ossicular tissue using a 1,053 nm Ti:Sapphire chirped pulse amplifier laser system configured to deliver ultrashort pulses of 350 femtoseconds (fs) (3.5x10(-13) seconds) in cadaver temporal bone.
STUDY DESIGN/MATERIALS AND METHODS: Ablation of the formalin-fixed incus and stapes was performed using an ultrashort pulse laser (USPL) (0.4 mm beam diameter, pulse fluence of 2.0 J/cm2, and pulse repetition rate of 10 Hz). The ablation rate was measured using optical micrometry, and crater surface morphology examined using scanning electron microscopy.
The laser produced precise bone ablation at a rate of 1.26 microm/pulse, with almost no evidence of thermal damage, and very little evidence of photomechanical injury.
Ultrashort pulse lasers may provide a useful clinical tool for otologic and skull base surgery, where precise hard tissue ablation is required adjacent to critical structures.
本研究的目的是在尸体颞骨中，使用配置为能产生350飞秒（fs）（3.5×10⁻¹³秒）超短脉冲的1053纳米钛宝石啁啾脉冲放大器激光系统，评估听小骨组织的消融情况。
研究设计/材料与方法：使用超短脉冲激光（USPL）（光束直径0.4毫米，脉冲能量密度2.0 J/cm²，脉冲重复频率10 Hz）对福尔马林固定的砧骨和镫骨进行消融。使用光学测微法测量消融速率，并用扫描电子显微镜检查弹坑表面形态。
该激光以1.26微米/脉冲的速率产生精确的骨消融，几乎没有热损伤的迹象，光机械损伤的迹象也非常少。
超短脉冲激光可能为耳科和颅底手术提供一种有用的临床工具，这些手术需要在关键结构附近进行精确的硬组织消融。
