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D-DNA的结构:八重螺旋还是七重螺旋?

Structure of D-DNA: 8-fold or 7-fold helix?

作者信息

Ramaswamy N, Bansal M, Gupta G, Sasisekharan V

机构信息

Molecular Biophysics Unit, Indian Institute of Science, Bangalore.

出版信息

EMBO J. 1983;2(9):1557-60. doi: 10.1002/j.1460-2075.1983.tb01623.x.

Abstract

We have shown that both right- and left-handed uniform helical models (RU and LU models) could be built to give satisfactory agreement with the fibre diffraction data of poly[d(I-C)] in the D-form. Atomic coordinates of these two models are reported in the present work. Molecular transforms of these two models, as well as of the recently published Hoogsteen base-paired 7-fold helical structure of Drew and Dickerson, are given. In view of the work of Drew and Dickerson, attention is drawn to the presence of clear 004 and 008 reflections in the diffraction patterns of poly[d(I-C)] and poly[d(A-T)]. The available data strongly suggest an 8-fold helical structure for the D-form of DNA.

摘要

我们已经表明,可以构建右手和左手均匀螺旋模型(RU和LU模型),使其与D型聚[d(I-C)]的纤维衍射数据达成令人满意的一致。本工作报道了这两种模型的原子坐标。给出了这两种模型以及最近发表的Drew和Dickerson的Hoogsteen碱基对7重螺旋结构的分子变换。鉴于Drew和Dickerson的工作,请注意聚[d(I-C)]和聚[d(A-T)]衍射图谱中清晰的004和008反射的存在。现有数据有力地表明DNA的D型具有8重螺旋结构。

相似文献

1
Structure of D-DNA: 8-fold or 7-fold helix?D-DNA的结构:八重螺旋还是七重螺旋?
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Structure of the alpha-form of poly[d(A)].poly[d(T)] and related polynucleotide duplexes.
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本文引用的文献

3
Left-handed helices for DNA: studies on poly[d(I-C)].DNA的左手螺旋:聚[d(I-C)]的研究
Proc Natl Acad Sci U S A. 1982 Oct;79(20):6109-13. doi: 10.1073/pnas.79.20.6109.

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