Ronne H, Lundgren S, Severinsson L, Rask L, Peterson P A
Department of Cell Research, University of Uppsala, Sweden.
EMBO J. 1983;2(9):1561-4. doi: 10.1002/j.1460-2075.1983.tb01624.x.
The submaxillary gland of the adult male mouse contains a number of serine proteases, several of which are involved in the proteolytic processing of precursors to growth factors and other biologically active polypeptides. Here we report the isolation and identification of a cDNA clone corresponding to one of the proteases, the type B of the epidermal growth factor-binding protein. A pronounced sequence homology was found between the predicted activation peptide of this protease and the NH2-terminal extension of the nerve growth factor alpha subunit, suggesting that the latter protein has an uncleaved activation peptide attached to its NH2 terminus.
成年雄性小鼠的颌下腺含有多种丝氨酸蛋白酶，其中几种参与生长因子前体和其他生物活性多肽的蛋白水解加工过程。在此，我们报告了与其中一种蛋白酶（表皮生长因子结合蛋白B型）相对应的cDNA克隆的分离和鉴定。在这种蛋白酶的预测激活肽与神经生长因子α亚基的NH2末端延伸之间发现了明显的序列同源性，这表明后者的蛋白在其NH2末端连接有一个未切割的激活肽。
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