Mrhar A, Kopitar Z, Kozjek F, Presl V, Karba R
Int J Clin Pharmacol Biopharm. 1979 Dec;17(12):476-81.
14C-Nitroxoline was given orally to the rats, and its distribution as well as plasma and bile levels were determined autoradiographically and by the aid of radioactivity measurements, respectively. Nitroxoline was also given to the human volunteers orally and intravenously in three various doses and the corresponding urine concentrations of unconjugated and conjugated nitroxoline were determined spectrophotometrically. A pharmacokinetical model was generated on the basis of the results. The curve fitting procedure between total nitroxoline cumulative quantities in urine and the model response simulated on analog-hybrid computer enabled the evaluation of the validity of the chosen model as well as of the identification of its parameters.
给大鼠口服14C-硝咯喹啉，分别通过放射自显影法和放射性测量法测定其分布以及血浆和胆汁水平。还对人类志愿者分别口服和静脉注射三种不同剂量的硝咯喹啉，并通过分光光度法测定相应的未结合和结合硝咯喹啉的尿液浓度。根据这些结果建立了药代动力学模型。尿液中总硝咯喹啉累积量与模拟混合计算机模拟的模型响应之间的曲线拟合程序，能够评估所选模型的有效性及其参数的识别。
