Mathiesen Henrik Kahr, Langkilde Annika Reynberg, Larsson Henrik B W
MR-afdelingen, H:S Hvidovre Hospital, DK-2650 Hvidovre.
Ugeskr Laeger. 2002 Feb 18;164(8):1031-6.
Conventional magnetic resonance imaging (MRI) techniques have proved important in the diagnosis and in the follow-up in clinical trials of patients with multiple sclerosis (MS). However, these techniques have low specificity for the pathological changes in the MS lesions, and the correlation between conventional MRI and the disability is poor. The last ten years have seen the development of new techniques with improved sensitivity and increased pathological specificity, such as magnetisation transfer imaging (MTI), magnetic resonance spectroscopy (MRS), diffusion-weighted imaging, and functional magnetic resonance imaging (fMRI). These techniques and their contribution to the knowledge about the pathophysiology of MS are described in this review.
传统磁共振成像（MRI）技术已被证明在多发性硬化症（MS）患者的诊断及临床试验随访中具有重要作用。然而，这些技术对MS病灶的病理变化特异性较低，且传统MRI与残疾程度之间的相关性较差。在过去十年中，出现了灵敏度提高且病理特异性增强的新技术，如磁化传递成像（MTI）、磁共振波谱分析（MRS）、扩散加权成像和功能磁共振成像（fMRI）。本文综述将介绍这些技术及其对MS病理生理学认识的贡献。
