对接触到展青霉的人而言，葡萄穗霉溶血素可能是出血的一个原因。
Stachylysin may be a cause of hemorrhaging in humans exposed to Stachybotrys chartarum.
作者信息
Vesper Stephen J, Vesper Mary Jo
机构信息
National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, Ohio 45268, USA.
出版信息
Infect Immun. 2002 Apr;70(4):2065-9. doi: 10.1128/IAI.70.4.2065-2069.2002.
Abstract
Stachybotrys chartarum is a toxigenic fungus that has been associated with human health concerns such as nasal bleeding in adults and pulmonary hemosiderosis (PH) in infants. Seven of eight strains of S. chartarum isolated from homes of infants with PH in Cleveland, Ohio, and the strain from the lung of an infant with PH in Texas produced stachylysin in tryptic soy broth (TSB), whereas only one out of eight strains isolated from control homes produced stachylysin. However, all strains produced stachylysin when grown on TSB with 0.7% sheep's blood. When stachylysin was injected into Lumbricus terrestis, the erythrocruorin hemoglobin (absorbance peaks at 280 and 415 nm) was released, resulting in a lethal effect. These results support the hypothesis that stachylysin may be one agent responsible for hemorrhaging in humans.
摘要
黑葡萄穗霉是一种产毒真菌，与人类健康问题有关，如成人鼻出血和婴儿肺含铁血黄素沉着症（PH）。从俄亥俄州克利夫兰患有PH的婴儿家中分离出的八株黑葡萄穗霉中有七株，以及从德克萨斯州一名患有PH的婴儿肺部分离出的菌株，在胰蛋白胨大豆肉汤（TSB）中产生了葡萄穗霉溶血素，而从对照家庭分离出的八株菌株中只有一株产生了葡萄穗霉溶血素。然而，当所有菌株在含有0.7%羊血的TSB上生长时，都会产生葡萄穗霉溶血素。当将葡萄穗霉溶血素注射到蚯蚓体内时，蚯蚓血红蛋白（吸光度峰值在280和415nm）被释放出来，从而产生致死效应。这些结果支持了葡萄穗霉溶血素可能是导致人类出血的一种因素的假说。
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