口腔扁平苔藓中的上皮内CD8 + T细胞与基底膜破坏
Intra-epithelial CD8+ T cells and basement membrane disruption in oral lichen planus.
作者信息
Zhou Xijing J, Sugerman Philip B, Savage Neil W, Walsh Laurence J, Seymour Gregory J
机构信息
Oral Biology & Pathology, School of Dentistry, The University of Queensland, Brisbane, Australia.
出版信息
J Oral Pathol Med. 2002 Jan;31(1):23-7. doi: 10.1046/j.0904-2512.2001.10063.x.
BACKGROUND
We investigated basement membrane (BM) disruption and the distribution of mast cells (MCs) and T cell subsets, in oral lichen planus (OLP) and normal buccal mucosa (NBM) using immunohistochemistry. In OLP, there were increased numbers of tryptase+ MCs in areas of BM disruption (P < 0.05).
METHOD
We identified clusters of intraepithelial CD8+ T cells in OLP, specifically in regions of BM disruption. The number of intraepithelial CD8+ T cells in regions of BM disruption was significantly greater than in regions of BM continuity (P < 0.05).
RESULTS
There were comparable numbers of lamina propria CD8+ T cells in regions of BM disruption and BM continuity. The number of CD4+ T cells in the epithelium and lamina propria of OLP lesions did not vary between regions of BM disruption and BM continuity.
CONCLUSION
These data suggest a role for MCs in epithelial BM disruption in OLP. CD8+ T cells may migrate through BM breaks to enter the OLP epithelium.
背景
我们使用免疫组织化学方法研究了口腔扁平苔藓（OLP）和正常颊黏膜（NBM）中基底膜（BM）的破坏情况以及肥大细胞（MCs）和T细胞亚群的分布。在OLP中，BM破坏区域的类胰蛋白酶阳性MCs数量增加（P < 0.05）。
方法
我们在OLP中，特别是在BM破坏区域，识别出上皮内CD8 + T细胞簇。BM破坏区域的上皮内CD8 + T细胞数量显著多于BM连续区域（P < 0.05）。
结果
BM破坏区域和BM连续区域的固有层CD8 + T细胞数量相当。OLP病变上皮和固有层中的CD4 + T细胞数量在BM破坏区域和BM连续区域之间没有差异。
结论
这些数据表明MCs在OLP上皮BM破坏中发挥作用。CD8 + T细胞可能通过BM断裂处迁移进入OLP上皮。
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