Hnilica Keith A, Medleau Linda
College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Rm c247, Knoxville, TN 37996, USA.
Vet Dermatol. 2002 Feb;13(1):23-8. doi: 10.1046/j.0959-4493.2001.00282.x.
Many Persian catteries have long-standing dermatophyte infections and are particularly difficult to treat. Enilconazole is a topical antifungal agent that has demonstrated good efficacy in recent studies. Twenty-two Persian cats naturally infected with Microsporum canis in a breeding cattery were treated with topical 0.2% enilconazole and monitored for 180 days. The treatments were repeated every 3 days for a total of eight applications. All the cats improved clinically and became culture negative by day 28. By day 180, four cats had developed clinical dermatophytosis and all cats had positive fungal cultures. In this study, topical 0.2% enilconazole was generally well tolerated but may have caused hypersalivation, idiopathic muscle weakness and slightly elevated serum alanine aminotransferase (ALT) concentrations. This study suggests that enilconazole may be used safely with little risk to the young, aged and gravid animals.
许多波斯猫繁育场长期存在皮肤癣菌感染，且特别难以治疗。烯丙康唑是一种局部用抗真菌剂，在最近的研究中已显示出良好疗效。对繁育场中自然感染犬小孢子菌的22只波斯猫外用0.2%烯丙康唑进行治疗，并监测180天。每3天重复治疗一次，共进行8次用药。所有猫在临床症状上均有改善，到第28天时真菌培养转为阴性。到第180天时，4只猫出现了临床皮肤癣菌病，所有猫的真菌培养均为阳性。在本研究中，外用0.2%烯丙康唑一般耐受性良好，但可能导致流涎过多、特发性肌无力以及血清丙氨酸氨基转移酶（ALT）浓度略有升高。本研究表明，烯丙康唑对幼龄、老龄和妊娠动物使用安全，风险很小。
