Guillot J, Malandain E, Jankowski F, Rojzner K, Fournier C, Touati F, Chermette R, Seewald W, Schenker R
Equipe de Mycologie, UMR 956 INRA-AFSSA-ENVA-Paris XII Biologie Moléculaire et Immunologie Parasitaires et Fongiques, France.
Vet Rec. 2002 Jun 8;150(23):714-8. doi: 10.1136/vr.150.23.714.
The efficacy of oral lufenuron, a chitin synthetase inhibitor, combined with topical enilconazole, was evaluated for the management of Microsporum canis infection in 100 cats housed in two catteries in France. The cats were treated with weekly rinses with enilconazole (0.2 per cent) for four weeks and, in each cattery, one group (A) was also treated with micronised griseofulvin (25 mg/kg administered orally twice a day for five weeks) and a second group (B) was treated with 60 mg/kg lufenuron administered orally once on day 0 and again after 30 days. All the cats were examined individually for cutaneous lesions and mycological cultures were made when the treatment began and after 15, 30, 60 and 90 days. In the first cattery, the cats' clinical scores after 30 and 60 days were significantly lower in group B than in group A. In both catteries and both treatment groups, the mean number of fungal colonies decreased rapidly during the first 15 days of treatment, remained stable for the following 45 days but increased from day 60 to the end of the experiment on day 90.
在法国的两个猫舍中，对100只感染犬小孢子菌的猫进行了研究，评估了几丁质合成酶抑制剂口服氟虫腈与局部应用烯丙康唑联合治疗的效果。猫每周用烯丙康唑（0.2%）冲洗四周，在每个猫舍中，一组（A组）还接受了微粉化灰黄霉素治疗（25mg/kg，口服，每日两次，共五周），另一组（B组）在第0天口服60mg/kg氟虫腈，30天后再次口服。对所有猫进行个体皮肤损伤检查，并在治疗开始时以及15、30、60和90天后进行真菌培养。在第一个猫舍中，B组猫在30天和60天后的临床评分显著低于A组。在两个猫舍的两个治疗组中，治疗的前15天真菌菌落平均数迅速下降，在接下来的45天保持稳定，但从第60天到实验结束的第90天有所增加。
