Mancianti Francesca, Dabizzi Sara, Nardoni Simona
Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, University of Pisa, Viale delle Piagge 2, I 56124 Pisa, Italy.
J Feline Med Surg. 2009 Feb;11(2):91-5. doi: 10.1016/j.jfms.2008.05.006. Epub 2008 Aug 5.
The effectiveness of enilconazole (4 weekly rinses with a 0.2% solution) or griseofulvin (50mg/kg twice daily for 40 days) following a pre-treatment with oral lufenuron (100mg/kg by-weekly for 8 weeks) was tested on 25 (11+14) Microsporum canis infected cats. Control animals were treated with lufenuron, griseofulvin and enilconazole alone. At day 150 pre-treated animals were culturally negative and clinically cured. While lufenuron alone was found to be ineffective against M canis infection, an immunomodulatory effect of the drug can be suggested, as reported in literature. Its use could be reserved to long-lasting infections, unsuccessfully treated with conventional drugs. Further studies are required to clearly establish the possible adjuvant effect of this molecule when used prior to enilconazole or griseofulvin.
在25只（11只+14只）感染犬小孢子菌的猫身上，测试了在口服氟虫腈（100mg/kg，每两周一次，共8周）预处理后，使用烯丙孕素（0.2%溶液，每周冲洗4次）或灰黄霉素（50mg/kg，每日两次，共40天）的效果。对照动物分别单独使用氟虫腈、灰黄霉素和烯丙孕素进行治疗。在第150天时，预处理动物的培养结果为阴性且临床治愈。虽然发现单独使用氟虫腈对犬小孢子菌感染无效，但正如文献报道的那样，该药物可能具有免疫调节作用。它可用于治疗常规药物治疗无效的持续性感染。需要进一步研究，以明确该分子在烯丙孕素或灰黄霉素之前使用时可能的辅助作用。
