Polychronopoulos P, Gioldasis G, Ellul J, Metallinos I C, Lekka N P, Paschalis C, Papapetropoulos Th
Department of Neurology, University Hospital of Patras, P.O. Box 1045, 26500, Rion-, Patras, Greece.
J Neurol Sci. 2002 Mar 30;195(2):117-22. doi: 10.1016/s0022-510x(01)00691-8.
Many studies have provided data showing that family history of stroke (FHS) is associated with an increased risk of stroke. The association of the FHS with the various stroke subtypes has not been adequately studied. The purpose of this study was to assess the association of the FHS with the two major stroke types (cerebral haematomas and ischaemic strokes) and the four stroke subtypes (cardioembolic, large artery disease, small artery disease, and undetermined) in a Greek population. The FHS was obtained from 421 consecutive acute stroke patients and from 239 matched control subjects. Positive FHS was observed in 49% of all stroke patients compared with 28% of the control subjects [adjusted OR=2.06 (95% confidence intervals (CI) 1.42-3.00)]. Haematomas, ischaemic strokes, and from the ischaemic strokes, both large and small artery disease strokes were strongly associated with positive FHS compared with the control subjects [adjusted OR=2.06 (95% CI 9-3.04), 2.07 (95% CI 1.09-3.91), 2.05 (95% CI 1.24-3.38), and 2.76 (95% CI 1.55-4.91), respectively]. There was no difference between maternal and paternal heritable contribution.In conclusion, FHS was found in this study to be an independent risk factor for all strokes combined, for each stroke type, and for the large and small-artery disease stroke subtypes, but not for the cardioembolic and undetermined stroke subtypes.
许多研究已提供数据表明，卒中家族史（FHS）与卒中风险增加相关。FHS与各种卒中亚型之间的关联尚未得到充分研究。本研究的目的是评估希腊人群中FHS与两种主要卒中类型（脑血肿和缺血性卒中）以及四种卒中亚型（心源性栓塞、大动脉疾病、小动脉疾病和不明原因）之间的关联。FHS数据来自421例连续的急性卒中患者和239例匹配的对照受试者。所有卒中患者中49%观察到FHS阳性，而对照受试者中这一比例为28%[校正比值比（OR）=2.06（95%置信区间（CI）1.42 - 3.00）]。与对照受试者相比，血肿、缺血性卒中以及缺血性卒中中的大动脉和小动脉疾病性卒中均与FHS阳性密切相关[校正OR分别为2.06（95%CI 1.49 - 3.04）、2.07（95%CI 1.09 - 3.91）、2.05（95%CI 1.24 - 3.38）和
