Ward Alister C, Lieschke Graham J
Centre for Cellular & Molecular Biology, School of Biological & Chemical Sciences, Deakin University, Burwood, Victoria, Australia.
Front Biosci. 2002 Apr 1;7:d827-33. doi: 10.2741/A814.
The zebrafish (Danio rerio) has been widely utilised for the study of developmental biology, which has lead to the evolution of sophisticated cellular and molecular approaches. More recently, the rapid progress of various zebrafish genomic infrastructure initiatives is facilitating the development of zebrafish models of human disease. This review aims to describe several representative examples of how the zebrafish can be successfully used to identify novel genes and assign gene function, providing invaluable clues to human pathophysiology.
斑马鱼（Danio rerio）已被广泛用于发育生物学研究，这推动了复杂细胞和分子方法的发展。最近，各种斑马鱼基因组基础设施计划的快速进展促进了人类疾病斑马鱼模型的开发。本综述旨在描述几个具有代表性的例子，说明斑马鱼如何能够成功用于鉴定新基因和确定基因功能，为人类病理生理学提供宝贵线索。
