Dooley K, Zon L I
Division of Hematology/Oncology, Department of Medicine, Children's Hospital, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.
Curr Opin Genet Dev. 2000 Jun;10(3):252-6. doi: 10.1016/s0959-437x(00)00074-5.
The zebrafish (Danio rerio) is a powerful model organism for the study of vertebrate biology, being well suited to both developmental and genetic analysis. Large-scale genetic screens have identified hundreds of mutant phenotypes, many of which resemble human clinical disorders. The creation of critical genetic reagents, coupled with the rapid progress of the zebrafish genome initiative directed by the National Institutes of Health, are bringing this model system to its full potential for the study of vertebrate biology, physiology and human disease.
斑马鱼（Danio rerio）是用于研究脊椎动物生物学的强大模式生物，非常适合发育分析和遗传分析。大规模遗传筛选已鉴定出数百种突变表型，其中许多类似于人类临床疾病。关键遗传试剂的创建，再加上美国国立卫生研究院主导的斑马鱼基因组计划的迅速进展，正使这个模式系统充分发挥其在脊椎动物生物学、生理学和人类疾病研究中的潜力。
