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Synergistic activities of macrolide antibiotics against Pseudomonas aeruginosa, Burkholderia cepacia, Stenotrophomonas maltophilia, and Alcaligenes xylosoxidans isolated from patients with cystic fibrosis.大环内酯类抗生素对从囊性纤维化患者中分离出的铜绿假单胞菌、洋葱伯克霍尔德菌、嗜麦芽窄食单胞菌和木糖氧化产碱菌的协同活性。
Antimicrob Agents Chemother. 2002 Apr;46(4):1105-7. doi: 10.1128/AAC.46.4.1105-1107.2002.
2
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3
In vitro activity of β-lactams in combination with avibactam against multidrug-resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Achromobacter xylosoxidans isolates from patients with cystic fibrosis.β-内酰胺类抗生素联合阿维巴坦对来自囊性纤维化患者的多重耐药铜绿假单胞菌、嗜麦芽寡养单胞菌和木糖氧化无色杆菌分离株的体外活性研究。
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Fluoroquinolone susceptibilities of efflux-mediated multidrug-resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Burkholderia cepacia.外排介导的多重耐药铜绿假单胞菌、嗜麦芽窄食单胞菌和洋葱伯克霍尔德菌对氟喹诺酮类药物的敏感性
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Transpl Infect Dis. 2018 Oct;20(5):e12955. doi: 10.1111/tid.12955. Epub 2018 Jun 25.
6
In vitro activity of doripenem against Pseudomonas aeruginosa and Burkholderia cepacia isolates from both cystic fibrosis and non-cystic fibrosis patients.多利培南对来自囊性纤维化和非囊性纤维化患者的铜绿假单胞菌和洋葱伯克霍尔德菌分离株的体外活性。
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Molecular epidemiology of Burkholderia cepacia, Stenotrophomonas maltophilia, and Alcaligenes xylosoxidans in a cystic fibrosis center.一家囊性纤维化中心里洋葱伯克霍尔德菌、嗜麦芽窄食单胞菌和木糖氧化产碱杆菌的分子流行病学研究
Eur J Clin Microbiol Infect Dis. 1996 Nov;15(11):876-9. doi: 10.1007/BF01691221.
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Comparative activity of antimicrobials against , and keratitis isolates.抗菌药物对 、 和 角膜炎分离株的活性比较。
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Influence of and on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.[此处原文不完整，缺少两个关键因素的具体内容]对铜绿假单胞菌多粘菌素药效学的影响以及阿奇霉素对群体感应抑制的意义
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Impact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis.阿奇霉素对妥布霉素治疗囊性纤维化的临床及抗菌效果的影响。
J Cyst Fibros. 2017 May;16(3):358-366. doi: 10.1016/j.jcf.2016.12.003. Epub 2016 Dec 24.

本文引用的文献

1
Identification and antimicrobial susceptibility of Alcaligenes xylosoxidans isolated from patients with cystic fibrosis.从囊性纤维化患者中分离出的木糖氧化产碱杆菌的鉴定及抗菌药敏性
J Clin Microbiol. 2001 Nov;39(11):3942-5. doi: 10.1128/JCM.39.11.3942-3945.2001.
2
Pulmonary outcome in cystic fibrosis is influenced primarily by mucoid Pseudomonas aeruginosa infection and immune status and only modestly by genotype.囊性纤维化的肺部预后主要受黏液型铜绿假单胞菌感染和免疫状态影响，而受基因型的影响较小。
Infect Immun. 1999 Sep;67(9):4744-50. doi: 10.1128/IAI.67.9.4744-4750.1999.
3
Evaluation of reference dilution test methods for antimicrobial susceptibility testing of Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis.对从囊性纤维化患者中分离出的铜绿假单胞菌菌株进行抗菌药物敏感性测试的参考稀释试验方法的评估。
J Clin Microbiol. 1999 Sep;37(9):2987-91. doi: 10.1128/JCM.37.9.2987-2991.1999.
4
Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group.囊性纤维化患者吸入妥布霉素的间歇性给药。囊性纤维化吸入妥布霉素研究组。
N Engl J Med. 1999 Jan 7;340(1):23-30. doi: 10.1056/NEJM199901073400104.
5
Microbiology of sputum from patients at cystic fibrosis centers in the United States.美国囊性纤维化中心患者痰液的微生物学研究。
Clin Infect Dis. 1998 Jul;27(1):158-63. doi: 10.1086/514631.
6
Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin.低剂量红霉素治疗弥漫性泛细支气管炎患者生存率的改善。
Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1829-32. doi: 10.1164/ajrccm.157.6.9710075.
7
Anti-inflammatory activity of macrolides: a new therapeutic potential?大环内酯类药物的抗炎活性：一种新的治疗潜力？
J Antimicrob Chemother. 1998 Mar;41 Suppl B:37-46. doi: 10.1093/jac/41.suppl_2.37.
8
Long-term azithromycin may improve lung function in children with cystic fibrosis.长期使用阿奇霉素可能改善囊性纤维化患儿的肺功能。
Lancet. 1998 Feb 7;351(9100):420. doi: 10.1016/S0140-6736(05)78360-4.
9
Inhibitory activity of clarithromycin on biofilm synthesis with Pseudomonas aeruginosa.克拉霉素对铜绿假单胞菌生物膜合成的抑制活性。
Acta Otolaryngol Suppl. 1996;525:56-60.
10
Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin.大环内酯类药物抗绿脓杆菌活性的直接证据：红霉素、克拉霉素和阿奇霉素的暴露依赖性杀菌活性及对蛋白质合成的抑制作用。
Antimicrob Agents Chemother. 1996 Oct;40(10):2271-5. doi: 10.1128/AAC.40.10.2271.

大环内酯类抗生素对从囊性纤维化患者中分离出的铜绿假单胞菌、洋葱伯克霍尔德菌、嗜麦芽窄食单胞菌和木糖氧化产碱菌的协同活性。

Synergistic activities of macrolide antibiotics against Pseudomonas aeruginosa, Burkholderia cepacia, Stenotrophomonas maltophilia, and Alcaligenes xylosoxidans isolated from patients with cystic fibrosis.

作者信息

Saiman Lisa, Chen Yunhua, Gabriel Pablo San, Knirsch Charles

机构信息

Department of Pediatrics, Columbia University, New York, New York 10032, USA.

出版信息

Antimicrob Agents Chemother. 2002 Apr;46(4):1105-7. doi: 10.1128/AAC.46.4.1105-1107.2002.

DOI:10.1128/AAC.46.4.1105-1107.2002
PMID:11897598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC127106/
Abstract

Azithromycin and clarithromycin were paired with other antibiotics to test synergistic activity against 300 multidrug-resistant pathogens isolated from cystic fibrosis (CF) patients. Clarithromycin-tobramycin was most active against Pseudomonas aeruginosa and inhibited 58% of strains. Azithromycin-trimethoprim-sulfamethoxazole, azithromycin-ceftazidime, and azithromycin-doxycycline or azithromycin-trimethoprim-sulfamethoxazole inhibited 40, 20, and 22% of Stenotrophomonas maltophilia, Burkholderia cepacia complex, and Achromobacter (Alcaligenes) xylosoxidans strains, respectively.

摘要

阿奇霉素和克拉霉素与其他抗生素配对，以测试对从囊性纤维化（CF）患者中分离出的300种多重耐药病原体的协同活性。克拉霉素-妥布霉素对铜绿假单胞菌的活性最强，可抑制58%的菌株。阿奇霉素-甲氧苄啶-磺胺甲恶唑、阿奇霉素-头孢他啶以及阿奇霉素-强力霉素或阿奇霉素-甲氧苄啶-磺胺甲恶唑分别抑制嗜麦芽窄食单胞菌、洋葱伯克霍尔德菌复合体和木糖氧化无色杆菌（嗜碱假单胞菌）菌株的比例为40%、20%和22%。