新型去氟喹诺酮类药物BMS 284756与其他七种抗菌药物对151株腐蚀艾肯菌的体外活性
In vitro activities of a new des-fluoroquinolone, BMS 284756, and seven other antimicrobial agents against 151 isolates of Eikenella corrodens.
作者信息
Goldstein Ellie J C, Citron Diane M, Merriam C Vreni, Warren Yumi A, Tyrrell Kerin L, Fernandez Helen
机构信息
The R. M. Alden Research Laboratory and UCLA Medical Center, Santa Monica, California 90404, USA.
出版信息
Antimicrob Agents Chemother. 2002 Apr;46(4):1141-3. doi: 10.1128/AAC.46.4.1141-1143.2002.
Abstract
The des-fluoroquinolone BMS 284756 was active in vitro against all 151 clinical strains of Eikenella corrodens at a MIC of < or = 0.25 microg/ml and was comparable in activity to moxifloxacin and levofloxacin. The MIC at which 90% of the isolates were inhibited by penicillin G was 2 microg/ml; MICs for 8.6% of the strains (13 of 151) were > or = 4 microg/ml, including for two beta-lactamase-producing isolates. Amoxicillin-clavulanate and ampicillin-sulbactam inhibited all strains at a MIC of < or = 1 microg/ml.
摘要
去氟喹诺酮BMS 284756在体外对151株啮蚀艾肯菌临床菌株均有活性，其最低抑菌浓度（MIC）≤0.25μg/ml，活性与莫西沙星和左氧氟沙星相当。青霉素G抑制90%分离株的MIC为2μg/ml；8.6%的菌株（151株中的13株）MIC≥4μg/ml，其中包括2株产β-内酰胺酶的分离株。阿莫西林-克拉维酸和氨苄西林-舒巴坦在MIC≤1μg/ml时可抑制所有菌株。
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