Laurová L, Jandová A, Skoda V I, Zizkovská E, Zizkovský V
Zentralbl Bakteriol Orig B. 1975;91(9):540-8.
In 18 patients with the histological proved Ca ovarii we have examined the level of serum immunoglobulins IgG, IgA and IgM in blood during the combined therapy by two cytostatics (Cyclophosphamide, Cytembena) in a week's intervals. The serum immunoglobins IgG, IgA, IgM was followed by the simple radial immunodiffusion technic by Manchini in 2% agar gel with the standard fa Sevac (CSSR). The level of IgG sank at least 10% in 10 patients, the level of IgA and IgG in 9 patients. We have also followed every month the level of the serum immunoglobins at the long times administration of several peroral doses of Cyclophosphamid in 9 patients. At this long times administration the serum immunoglobins IgG and IgA were found responsible in their reduced synthesis than the IgM.
在18例经组织学证实为卵巢癌的患者中，我们在联合使用两种细胞抑制剂（环磷酰胺、塞替派）进行治疗期间，每隔一周检测一次血液中血清免疫球蛋白IgG、IgA和IgM的水平。血清免疫球蛋白IgG、IgA、IgM采用曼基尼在2%琼脂凝胶中用标准法Sevac（捷克斯洛伐克）的单向放射免疫扩散技术进行检测。10例患者的IgG水平至少下降了10%，9例患者的IgA和IgG水平下降。我们还对9例长期口服数剂环磷酰胺的患者每月跟踪检测血清免疫球蛋白水平。在这种长期给药过程中，发现血清免疫球蛋白IgG和IgA合成减少比IgM更明显。
