Lim Hyunjung, Song Haengseok, Paria B C, Reese Jeff, Das Sanjoy K, Dey S K
Department of Molecular and Integrative Physiology, Ralph L. Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160-7338, USA.
Vitam Horm. 2002;64:43-76. doi: 10.1016/s0083-6729(02)64002-6.
Synchronized development of the embryo to the active stage of the blastocyst, differentiation of the uterus to the receptive state, and a "cross talk" between the blastocyst and uterine luminal epithelium are essential to the process of implantation. In spite of considerable accumulation of information and the present state of the knowledge, our understanding of the definitive mechanisms that regulate these events remains elusive. Although there are species variations in the process of implantation, many basic similarities do exist among various species. This review focuses on specific aspects of the implantation process in mice with the hope that many of the findings will be relevant to the process in humans. To establish signaling mechanisms of embryo-uterine interactions during implantation, studies on both embryonic and uterine consequences are required to generate more meaningful information. Due to ethical restriction and experimental limitation, it is difficult to generate such information in humans. This review has attempted to provide a comprehensive, but not complete, narration of a number of embryonic and uterine factors that are involved in the process of implantation in autocrine, paracrine, and/or juxtacrine manners in mice at the physiological, cellular, molecular, and genetic levels.
胚胎同步发育至囊胚活跃阶段、子宫分化为接受状态以及囊胚与子宫腔上皮之间的“串扰”对于着床过程至关重要。尽管积累了大量信息以及目前的知识状态，但我们对调控这些事件的明确机制的理解仍然难以捉摸。虽然着床过程存在物种差异，但不同物种之间确实存在许多基本相似之处。本综述聚焦于小鼠着床过程的特定方面，希望许多研究结果与人类的该过程相关。为了确立着床期间胚胎 - 子宫相互作用的信号传导机制，需要对胚胎和子宫的影响进行研究以产生更有意义的信息。由于伦理限制和实验局限，很难在人类中获取此类信息。本综述试图全面但非完整地叙述一些在生理、细胞、分子和遗传水平上以自分泌、旁分泌和/或近分泌方式参与小鼠着床过程的胚胎和子宫因素。
