Tenser R B
Division of Neurology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Curr Neurol Neurosci Rep. 2001 Nov;1(6):526-32. doi: 10.1007/s11910-001-0057-z.
Varicella-zoster virus (VZV), the cause of chicken pox, establishes latent infection in sensory ganglia. Reactivation results in zoster (shingles), sometimes complicated by encephalitis (myelitis). Postherpetic neuralgia (PHN) is the major morbidity of zoster. PHN typically increases in frequency with age. The VZV vaccine, which was developed for children, may be effective in enhancing VZV immune reactivity and decreasing zoster in adults. Early antiviral treatment may be effective in decreasing PHN onset. Several other medications may be useful in treating established PHN. A recent report discussed intrathecal steroid use.
水痘带状疱疹病毒（VZV）是水痘的病原体，可在感觉神经节中建立潜伏感染。病毒再激活会导致带状疱疹，有时会并发脑炎（脊髓炎）。带状疱疹后神经痛（PHN）是带状疱疹的主要并发症。PHN的发病率通常随年龄增长而增加。为儿童研发的VZV疫苗可能有助于增强成人的VZV免疫反应并减少带状疱疹的发生。早期抗病毒治疗可能有助于减少PHN的发病。其他几种药物可能对已确诊的PHN有效。最近有一份报告讨论了鞘内注射类固醇的使用。
