Hanford Michael J, Peeples Tonya L
Department of Chemical and Biochemical Engineering, Center for Biocatalysis and Bioprocessing, The University of Iowa, Iowa City 52242, USA.
Appl Biochem Biotechnol. 2002 Jan;97(1):45-62. doi: 10.1385/abab:97:1:45.
The extremely stable biomolecules manufactured by organisms from extreme environments are of great scientific and engineering interest in the development of robust and stable industrial biocatalysts. Identification of molecules that impart stability under extremes will also have a profound impact on our understanding of cellular survival. This review discusses isolation and characterization of archaeal tetraethers as well as target technologies for tetraether lipid application. The isolation and characterization of archaeal tetraether lipids has led to some interesting applications improving on ester lipid technologies. Potential applications include novel lubricants, gene-delivery systems, monolayer lipid matrices for sensor devices, and protein stabilization. Following this review, patent abstracts and additional literature pertaining to the isolation, characterization, and application of archaeal membrane lipids are listed.
极端环境中的生物体制造的极其稳定的生物分子，在开发强大且稳定的工业生物催化剂方面具有重大的科学和工程意义。鉴定在极端条件下赋予稳定性的分子，也将对我们理解细胞存活产生深远影响。本综述讨论了古菌四醚的分离与表征以及四醚脂质应用的靶向技术。古菌四醚脂质的分离与表征已带来了一些改进酯类脂质技术的有趣应用。潜在应用包括新型润滑剂、基因递送系统、用于传感设备的单层脂质基质以及蛋白质稳定化。在本综述之后，列出了与古菌膜脂质的分离、表征和应用相关的专利摘要及其他文献。
