Conway D P, Mathis G F, Lang M
Conway Associates, Asbury, New Jersey 08802, USA.
Poult Sci. 2002 Mar;81(3):349-52. doi: 10.1093/ps/81.3.349.
A 49-d floor pen study was conducted with broiler chickens to compare the effects of different anticoccidial withdrawal times on the efficacy of 1 ppm diclazuril. The starter diet in three treatments contained 66 ppm salinomycin + 50 ppm roxarsone (3-nitro-4-hydroxyphenylarsonic acid), followed by 1 ppm diclazuril in the grower diet commencing on Day 17. Diclazuril was withdrawn from these treatments on Day 28, 35, or 42 (finisher diet), respectively. Two other treatments in the study were given 66 ppm salinomycin + 50 ppm roxarsone in the starter and grower diets to Day 28 or no anticoccidial (unmedicated). The starter (Days 0 to 16), grower (Days 17 to 35), and finisher (Days 36 to 49) diets in each treatment included 55 ppm bacitracin methylene disalicylate for growth promotion. Fifty 1-d-old chicks were randomly allotted to each of 10 pens per treatment using a randomized complete block design. Birds in each pen were raised on litter naturally contaminated with a mixture of Eimeria acervulina, Eimeria maxima, and Eimeria tenella. The results demonstrated that some performance loss occurred in the salinomycin Day 28 treatment. Means for weight gain and feed conversion on Day 49 were improved (P < 0.05) in each diclazuril treatment in comparison with the salinomycin and unmedicated treatments. Feed conversion means in the diclazuril Day 35 and Day 42 treatments were improved (P < 0.05) in comparison with the diclazuril Day 28 treatment, indicating that shorter withdrawal times provided further benefit.
用肉鸡进行了一项为期49天的地面围栏试验，以比较不同抗球虫停药时间对1 ppm地克珠利疗效的影响。三种处理的雏鸡日粮中含有66 ppm沙利霉素+50 ppm洛克沙胂（3-硝基-4-羟基苯胂酸），从第17天开始，生长鸡日粮中添加1 ppm地克珠利。这些处理分别在第28天、35天或42天（育肥鸡日粮）停止用地克珠利。该研究中的另外两种处理在雏鸡和生长鸡日粮中至第28天给予66 ppm沙利霉素+50 ppm洛克沙胂，或不使用抗球虫药（未用药）。每种处理的雏鸡（第0至16天）、生长鸡（第17至35天）和育肥鸡（第36至49天）日粮中均含有55 ppm杆菌肽亚甲基二水杨酸酯以促进生长。采用随机完全区组设计，将50只1日龄雏鸡随机分配到每处理的10个围栏中。每个围栏中的鸡饲养在自然感染堆型艾美耳球虫、巨型艾美耳球虫和柔嫩艾美耳球虫混合物的垫料上。结果表明，沙利霉素第28天处理组出现了一些生产性能损失。与沙利霉素和未用药处理相比，各用地克珠利处理组在第49天的体重增加和饲料转化率平均值有所改善（P<0.05）。与地克珠利第28天处理相比，地克珠利第35天和第42天处理组的饲料转化率平均值有所改善（P<0.05），表明停药时间越短，效益越大。
