Koretz R L, Gitnick G L
Am J Med. 1975 Dec;59(6):754-60. doi: 10.1016/0002-9343(75)90460-x.
Aliquots from units of blood were screened by radioimmunoassay (RIA) and reverse passive hemagglutination (RPHA) shortly after transfusion. Recipients of positive units, as well as control subjects, were followed prospectively for evidence of either post-transfusion hepatitis (PTH) or exposure to hepatitis B (HB). There was a significant correlation between receipt of either an RPHA-positive or RIA-confirmed positive unit and the subsequent development of PTH or HB exposure. Recipients of all volunteer units had a lower incidence of PTH than did recipients of all commercial units. The frequency of PTH and HB exposure was not statistically different in groups receiving 1 to 5, 6 to 10, 11 to 20 and greater or less than 21 units of blood. The PTH seen in the study presented over a wide clinical spectrum, but it was usually anicteric and frequently asymptomatic.
输血后不久，通过放射免疫测定法（RIA）和反向被动血凝试验（RPHA）对血液单位的等分试样进行筛查。对接受阳性单位血液的受血者以及对照受试者进行前瞻性随访，以寻找输血后肝炎（PTH）或接触乙型肝炎（HB）的证据。接受RPHA阳性或RIA确认阳性单位血液与随后发生PTH或HB接触之间存在显著相关性。所有志愿供血单位的受血者发生PTH的发生率低于所有商业供血单位的受血者。接受1至5单位、6至10单位、11至20单位以及超过或少于21单位血液的组中，PTH和HB接触的频率在统计学上没有差异。该研究中观察到的PTH临床表现范围广泛，但通常无黄疸且常常无症状。
