Gottesman Michael M, Fojo Tito, Bates Susan E
Laboratory of Cell Biology and Cancer Therapeutics Branch, The Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA.
Nat Rev Cancer. 2002 Jan;2(1):48-58. doi: 10.1038/nrc706.
Chemotherapeutics are the most effective treatment for metastatic tumours. However, the ability of cancer cells to become simultaneously resistant to different drugs--a trait known as multidrug resistance--remains a significant impediment to successful chemotherapy. Three decades of multidrug-resistance research have identified a myriad of ways in which cancer cells can elude chemotherapy, and it has become apparent that resistance exists against every effective drug, even our newest agents. Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy.
化疗药物是转移性肿瘤最有效的治疗方法。然而，癌细胞同时对不同药物产生耐药性的能力——即所谓的多药耐药性——仍然是成功化疗的重大障碍。三十年来对多药耐药性的研究已经确定了癌细胞逃避化疗的多种方式，而且很明显，每种有效药物甚至是最新的药物都存在耐药性。因此，预测和规避耐药性的能力可能会改善化疗效果。
