Mandal Debabrata, Moitra Prasun K, Saha Samiran, Basu Joyoti
Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Road, 700009, Kolkata, India.
FEBS Lett. 2002 Feb 27;513(2-3):184-8. doi: 10.1016/s0014-5793(02)02294-9.
The appearance of phosphatidylserine (PS) on the outer surface of red cells is an important signal for their uptake by macrophages. We report for the first time that procaspase 3 present in the anucleated mature human erythrocyte is activated under oxidative stress induced by t-butylhydroperoxide leading to impairment of the aminophospholipid translocase, PS externalization and increased erythrophagocytosis. This is the first report linking caspase 3 activation to inhibition of flippase activity and uptake of red cells by macrophages.
红细胞外表面磷脂酰丝氨酸（PS）的出现是其被巨噬细胞摄取的重要信号。我们首次报道，无核成熟人类红细胞中存在的procaspase 3在叔丁基过氧化氢诱导的氧化应激下被激活，导致氨基磷脂转位酶受损、PS外化以及红细胞吞噬作用增加。这是首次将caspase 3激活与翻转酶活性抑制及巨噬细胞对红细胞的摄取联系起来的报道。
