凋亡T淋巴细胞上作为吞噬细胞识别信号的磷脂酰丝氨酸暴露机制。
Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes.
作者信息
Verhoven B, Schlegel R A, Williamson P
机构信息
Department of Biology, Amherst College, Massachusetts 01002, USA.
出版信息
J Exp Med. 1995 Nov 1;182(5):1597-601. doi: 10.1084/jem.182.5.1597.
Abstract
The appearance of phosphatidylserine (PS) on the cell surface during apoptosis in thymocytes and cytotoxic T lymphocyte cell lines provokes PS-dependent recognition by activated macrophages. Flow cytometric analysis of transbilayer lipid movements in T lymphocytes undergoing apoptosis reveals that downregulation of the adenosine triphosphate-dependent amino-phospholipid translocase and activation of a nonspecific lipid scramblase are responsible for PS reaching the surface from its intracellular location. Both mechanisms are expressed at the same time, and precede DNA degradation, zeiosis, and cell lysis in the apoptotic pathway.
摘要
在胸腺细胞和细胞毒性T淋巴细胞系凋亡过程中，细胞表面磷脂酰丝氨酸（PS）的出现引发了活化巨噬细胞对PS的依赖性识别。对经历凋亡的T淋巴细胞跨膜脂质运动的流式细胞术分析表明，三磷酸腺苷依赖性氨基磷脂转位酶的下调和非特异性脂质翻转酶的激活导致PS从细胞内位置到达细胞表面。这两种机制同时表达，并在凋亡途径中DNA降解、膜泡形成和细胞裂解之前发生。
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