卡那霉素链霉菌形成卡那霉素的矿物质营养
Mineral nutrition of Streptomyces kanamyceticus for kanamycin formation.
作者信息
Basak K, Majumdar S K
出版信息
Antimicrob Agents Chemother. 1975 Oct;8(4):391-5. doi: 10.1128/AAC.8.4.391.
Abstract
Kanamycin production by Streptomyces kanamyceticus ATCC 12853 requires magnesium sulfate and potassium phosphate at concentrations of 0.4 and 1.0 g per liter, respectively. The optimal concentrations of Fe and Zn for production of kanamycin are 0.25 and 0.575 mug/ml, respectively, whereas Mo at 0.04 mug/ml allows maximal cellular growth and antibiotic synthesis. Mn and Ca are without any effect. Cu, Co, Ni, and V have inhibitory effect on growth of the organism as well as kanamycin formation.
摘要
卡那霉素链霉菌ATCC 12853生产卡那霉素需要硫酸镁和磷酸钾，其浓度分别为每升0.4克和1.0克。生产卡那霉素的铁和锌的最佳浓度分别为0.25微克/毫升和0.575微克/毫升，而0.04微克/毫升的钼可使细胞生长和抗生素合成达到最大。锰和钙没有任何影响。铜、钴、镍和钒对该生物体的生长以及卡那霉素的形成具有抑制作用。
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