Verma R J, Chinoy N J
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, India.
Asian J Androl. 2002 Mar;4(1):77-8.
To evaluate the administration of Carica papaya seed extract on the contractility of cauda epididymal tubules in male rats.
Adult male albino rats were administered intramuscularly papaya seed extract at a dose of 0.5 mg/kg/day for 7 days. Animals were killed, cauda epididymal tubules of 5 cm length were isolated and the contractile response to different concentrations of adrenalin (1-500 microg/25mL) was examined. In another group of animals, the contractile response was assayed 3 months after withdrawal of the treatment.
Papaya seed extract brought about a significant decrease in the contractile response of epididymal tubules as compared with the control. After three months of papaya withdrawal, a nearly normal pattern of contraction was regained.
Papaya seed treatment reversibly reduces the contractile response of cauda epididymal tubules.
评估番木瓜籽提取物对雄性大鼠附睾尾部小管收缩性的影响。
成年雄性白化大鼠肌肉注射剂量为0.5毫克/千克/天的番木瓜籽提取物，持续7天。处死动物后，分离出5厘米长的附睾尾部小管，检测其对不同浓度肾上腺素（1 - 500微克/25毫升）的收缩反应。在另一组动物中，停药3个月后检测收缩反应。
与对照组相比，番木瓜籽提取物使附睾小管的收缩反应显著降低。停用番木瓜籽3个月后，收缩模式几乎恢复正常。
番木瓜籽处理可使附睾尾部小管的收缩反应可逆性降低。
