Vaïsse V, Clerici T, Fusade T
Unité de Dermatologie, Hôpital Tenon, 4, rue de la Chine, 75020 Paris.
Ann Dermatol Venereol. 2001 Nov;128(11):1220-4.
Cutaneous Bowen's disease is an intra-epidermal squamous cell carcinoma.
Ten cases of cutaneous Bowen's disease diagnosed among 8 patients were treated by scanned high energy carbon dioxide laser between November 1996, and March 1998. A biopsy was performed in all patients before treatment.
The post-treatment follow-up extended from 1 to 4 years with an average follow-up of 2 years and 11 months. Only one patient, whose lesion was located on the auricle, presented a recurrence after one year. The remaining patients did not present any recurrence during their last control: six patients were followed for two years or more and one patient for one year. We demonstrate a histological and clinical correlation between the number of carbon dioxide laser passes before a clinical endpoint and the thickness of the epidermal carcinoma treated.
This new treatment has comparable efficacy to other treatments. It can be applied to extensive lesions without sequelae except for the risk of residual hypopigmentation.
皮肤鲍温病是一种表皮内鳞状细胞癌。
1996年11月至1998年3月期间,对8例患者诊断出的10例皮肤鲍温病采用扫描高能二氧化碳激光进行治疗。所有患者在治疗前均进行了活检。
治疗后的随访时间为1至4年,平均随访时间为2年11个月。只有1例病变位于耳廓的患者在1年后复发。其余患者在最后一次复查时均未出现复发:6例患者随访2年或更长时间,1例患者随访1年。我们证明了在达到临床终点前二氧化碳激光照射次数与所治疗的表皮癌厚度之间存在组织学和临床相关性。
这种新疗法与其他疗法具有相当的疗效。它可应用于广泛病变,除有残留色素减退的风险外无后遗症。