皮肤原位鳞状细胞癌（鲍温病）：莫氏显微外科手术治疗
Cutaneous squamous carcinoma in situ (Bowen's disease): treatment with Mohs micrographic surgery.
作者信息
Leibovitch Igal, Huilgol Shyamala C, Selva Dinesh, Richards Shawn, Paver Robert
机构信息
Oculoplastic and Orbital Division, Department of Ophthalmology and Visual Sciences, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia.
出版信息
J Am Acad Dermatol. 2005 Jun;52(6):997-1002. doi: 10.1016/j.jaad.2004.12.033.
BACKGROUND
Bowen's disease (BD), also known as squamous intraepidermal carcinoma, is a malignant skin tumor with a potential to progress to invasive carcinoma.
OBJECTIVE
We sought to report a large series of patients with BD treated with Mohs micrographic surgery (MMS).
METHODS
This prospective, multicenter, case series included all patients in Australia treated with MMS for BD, who were monitored by the Skin and Cancer Foundation between 1993 and 2002.
RESULTS
There were 270 cases; the majority (93.4%) were located in the head and neck area. In 50.7% of cases it was a recurrent tumor. In 20% the tumor was initially misdiagnosed as basal cell carcinoma or squamous cell carcinoma. No cases with perineural invasion were diagnosed. There were 6 cases of recurrence (6.3%) of 95 patients who completed a 5-year follow-up period after MMS.
CONCLUSION
The low 5-year recurrence rate of BD with MMS emphasizes the importance of margin-controlled excision, especially in the head and neck area where tissue preservation is essential.
背景
鲍恩病（BD），也称为鳞状上皮内癌，是一种有进展为浸润性癌潜能的恶性皮肤肿瘤。
目的
我们试图报告一大组接受莫氏显微外科手术（MMS）治疗的鲍恩病患者。
方法
这项前瞻性、多中心病例系列研究纳入了1993年至2002年间在澳大利亚接受MMS治疗BD的所有患者，这些患者由皮肤与癌症基金会进行监测。
结果
共有270例病例；大多数（93.4%）位于头颈部区域。50.7%的病例为复发性肿瘤。20%的肿瘤最初被误诊为基底细胞癌或鳞状细胞癌。未诊断出伴有神经周围浸润的病例。在95例接受MMS后完成5年随访期的患者中，有6例复发（6.3%）。
结论
MMS治疗鲍恩病的5年低复发率强调了切缘控制切除的重要性，尤其是在对头颈部区域至关重要的组织保留方面。
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