Stermer Edy
Department of Gastroenterology, Bnei Zion Medical Center, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Isr Med Assoc J. 2002 Mar;4(3):200-2.
Alcohol is one of the most commonly abused drugs, with a per capita consumption of approximately 10 L pure ethanol per year in the United States and even higher in Spain and France. In terms of mortality, the effect of alcohol on the liver and the pancreas is probably more significant than on the tubular gastrointestinal tract. However, alcohol is a very important cause of morbidity in the tubular gastrointestinal tract. Alcohol influences the motility in the esophagus, stomach and small bowel and has direct effects on the mucosa of the upper tract. While the stimulation of gastric acid secretion is inversely correlated with the alcohol concentration of the beverage, a direct pathogenetic role in peptic ulcer disease has not been demonstrated. Some alcohols, like red wine, have been shown to possess an anti-Helicobacter pylori effect. Alcohol also has a role in the development of tumors of the gastrointestinal tract.
酒精是最常被滥用的药物之一，在美国人均每年纯乙醇消费量约为10升，在西班牙和法国甚至更高。就死亡率而言，酒精对肝脏和胰腺的影响可能比对胃肠道的影响更为显著。然而，酒精是胃肠道发病的一个非常重要的原因。酒精会影响食管、胃和小肠的蠕动，并对上消化道黏膜有直接影响。虽然胃酸分泌的刺激与饮料中的酒精浓度呈负相关，但尚未证实其在消化性溃疡疾病中有直接致病作用。一些酒类，如红酒，已被证明具有抗幽门螺杆菌的作用。酒精在胃肠道肿瘤的发生发展中也起作用。
