Sowinski J A, Battista G W, Petrone M E, Chaknis P, Zhang Y P, DeVizio W, Volpe A R, Proskin H M
Dental Hygiene Department, Erie County College, Williamsville, New York, USA.
Compend Contin Educ Dent Suppl. 2000(27):11-6; quiz 28.
An 8-week, double-blind, three-way clinical trial compared the dentinal hypersensitivity-reducing effectiveness of a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride in a silica base (Colgate Sensitive Maximum Strength Toothpaste, Colgate-Palmolive Co.) with a commercially available desensitizing dentifrice containing 5.0% potassium nitrate and 0.243% sodium fluoride in a silica base (Sensodyne Fresh Mint Toothpaste, Block Drug Company, Inc.) and a nondesensitizing dentifrice containing 0.243% sodium fluoride in a silica base (Colgate Winterfresh Gel, Colgate-Palmolive Co.). One hundred nine subjects were stratified into three balanced groups according to gender, age, mean baseline tactile (Yeaple Probe), and thermal (air blast) scores. The test products were randomly assigned to each group with instructions to brush twice daily. Oral examinations with tactile and thermal assessments were repeated after 4 and 8 weeks. The new dentifrice group demonstrated statistically significant improvements in tactile and thermal sensitivity over the two control groups.
一项为期8周的双盲三向临床试验，比较了一种新型含5.0%硝酸钾和0.454%氟化亚锡的二氧化硅基牙膏（高露洁敏感极致护龈牙膏，高露洁棕榄公司）、一种市售含5.0%硝酸钾和0.243%氟化钠的二氧化硅基脱敏牙膏（舒适达清新薄荷牙膏，博克药物公司）以及一种含0.243%氟化钠的二氧化硅基非脱敏牙膏（高露洁冰爽薄荷啫喱牙膏，高露洁棕榄公司）在降低牙本质过敏方面的效果。109名受试者根据性别、年龄、平均基线触觉（耶普尔探针）和热（气喷）评分被分层为三个均衡组。将测试产品随机分配到每个组，并指示每天刷牙两次。在4周和8周后重复进行触觉和热评估的口腔检查。与两个对照组相比，新型牙膏组在触觉和热敏感性方面有统计学显著改善。
