Schiff T, Zhang Y P, DeVizio W, Stewart B, Chaknis P, Petrone M E, Volpe A R, Proskin H M
University of the Pacific School of Dentistry, San Francisco, California, USA.
Compend Contin Educ Dent Suppl. 2000(27):4-10; quiz 28.
The effect on dentinal hypersensitivity from the use of a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride in a silica base (Colgate Sensitive Maximum Strength Toothpaste, Colgate-Palmolive Co.) over an 8-week period was compared to a commercially available dentifrice containing 5.0% potassium nitrate and 0.243% sodium fluoride in a silica base (positive control [Sensodyne Fresh Mint Toothpaste, Block Drug Company, Inc.]) and to a commercially available nondesensitizing dentifrice containing 0.243% sodium fluoride in a silica base (negative control [Colgate Winterfresh Gel, Colgate-Palmolive Co.]). A total of 120 participants were stratified into 3 balanced groups according to baseline mean air blast (thermal) and tactile (Yeaple Probe) sensitivity scores, gender, and age. Participants brushed their teeth twice daily (morning and evening) for 1 minute. Dentinal hypersensitivity examinations were conducted at baseline, 4 weeks, and 8 weeks by the same dental examiner. After 4- and 8-weeks' use of their assigned products, participants in the new dentifrice group demonstrated statistically significant improvements (p < 0.05) in tactile and air blast sensitivity, as compared to those using the positive and negative control dentifrices.
将含5.0%硝酸钾和0.454%氟化亚锡的新型二氧化硅基牙膏（高露洁超强敏感牙膏，高露洁棕榄公司）使用8周对牙本质过敏的影响，与含5.0%硝酸钾和0.243%氟化钠的市售二氧化硅基牙膏（阳性对照[舒适达清新薄荷牙膏，布洛克制药公司]）以及含0.243%氟化钠的市售非脱敏二氧化硅基牙膏（阴性对照[高露洁冰爽牙膏，高露洁棕榄公司]）进行了比较。根据基线平均气喷（热）和触觉（耶普尔探针）敏感度评分、性别和年龄，将总共120名参与者分为3个均衡组。参与者每天早晚刷牙两次，每次1分钟。由同一名牙科检查人员在基线、4周和8周时进行牙本质过敏检查。在使用指定产品4周和8周后，与使用阳性和阴性对照牙膏的参与者相比，新型牙膏组的参与者在触觉和气喷敏感度方面有统计学上的显著改善（p<0.05）。
