Yon J, Christensen J
Ann Surg. 1975 Dec;182(6):672-6. doi: 10.1097/00000658-197512000-00002.
A series of 78 patients with achalasia, seen during a 10-year period, was like those reported by others with regard to age at onset, nature of symptoms, and duration of symptoms. Analysis of the results of 5 different treatment modalities administered allows an uncontrolled comparison heretofore not available from an institution at which no one treatment was favored over all others. Those who were not treated or who received only anticholinergic medication did not become asymptomatic. Those treated by single or repeated bougienage were not improved for more than a few weeks and suffered a 6% incidence of esophageal perforation. Forty-six per cent of those treated by a single pneumatic dilatation were asymptomatic for 1 year or more. Although esophagocardiomyotomy provided symptomatic relief for 1 year or more in 85%, there was a 25% incidence of gastroesophageal reflux.
在10年期间诊治的78例贲门失弛缓症患者，在发病年龄、症状特点及症状持续时间方面与其他报告的病例相似。对所采用的5种不同治疗方式的结果进行分析，得以进行一种不受控制的比较，而这是以往在没有一种治疗方法比其他方法更受青睐的机构中无法做到的。未接受治疗或仅接受抗胆碱能药物治疗的患者未实现症状消失。接受单次或反复探条扩张治疗的患者在数周以上时间内并无改善，且食管穿孔发生率为6%。单次气囊扩张治疗的患者中有46%在1年或更长时间内无症状。尽管食管贲门肌层切开术使85%的患者在1年或更长时间内症状缓解，但胃食管反流发生率为25%。
