Awouters F, Niemegeers C J, Kuyps J, Janssen P A
Arch Int Pharmacodyn Ther. 1975 Sep;217(1):29-37.
The time-course of castor oil-induced diarrhea in fasted rats was quantified by weighing stools every 15 minutes for 8 hours after the challenge and then after 24 hours. Diarrhea began within 1 hour as a series of rapidly occurring evacuations over 20 to 40 minutes. The mean weight of these stools was 5.7 g; later irregular evacuations increased the weight to 9.4 g at 8 hours. The area of individual time-weight diagrams had a median value of 432 units. Pretreatment with 0.16 mg/kg of loperamide, a new antidiarrheal drug, significantly decreased the area of similarly obtained diagrams; 0.31 mg/kg caused a 50% reduction. This antagonism by loperamide of castor oil-induced diarrhea may involve reduction in the severity of inflammatory changes in the intestinal wall.
在禁食大鼠中，蓖麻油诱发腹泻的时程通过在给予蓖麻油刺激后每15分钟称一次粪便重量来量化，持续8小时，之后再持续24小时。腹泻在1小时内开始，表现为在20至40分钟内迅速发生的一系列排便。这些粪便的平均重量为5.7克；随后的不规则排便使8小时时的粪便重量增加到9.4克。各个时间-重量图的面积中位数为432单位。用0.16毫克/千克的洛哌丁胺（一种新型止泻药）进行预处理，可显著降低类似获得的图的面积；0.31毫克/千克可使其减少50%。洛哌丁胺对蓖麻油诱发腹泻的这种拮抗作用可能涉及减轻肠壁炎症变化的严重程度。
