Shahed-Al-Mahmud Md, Shawon Md Jalal Ahmed, Islam Tariqul, Rahman Md Mahmudur, Rahman Md Rashidur
1Present Address: Department of Microbiology and Immunology, School of Medicine, Tzu Chi University, No. 701, Sec. 3, Zhongyang Rd., Hualien, 97004 Taiwan.
2Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka, 1217 Bangladesh.
Indian J Clin Biochem. 2020 Jan;35(1):72-79. doi: 10.1007/s12291-018-0781-7. Epub 2018 Jul 21.
Lour., traditionally used for anti-diarrheal effects as like dysentery and diarrhea. The present study aims to prove the anti-diarrheal activities of methanolic extract of leaves of in animal models. The anti-diarrheal activity was evaluated using castor oil-induced diarrhea and magnesium sulphate-induced diarrhea models whereas anti-motility activities were investigated using gastrointestinal transit test examined in animal models. In castor oil-induced diarrhea model, methanolic extract of (MESA) at the doses of 100, 200, and 400 mg/kg produced statistically significant ( < 0.001) decreased the number of diarrheal feces of rats against castor oil-induced diarrhea as well as magnesium sulphate-induced diarrhea model also showed the same manner. In gastrointestinal transit test, delayed gastric emptying time decreased significantly ( < 0.001), the propulsion of charcoal meal in the gastrointestinal tract which also showed a dose-dependent manner in rats. The recent study indicates that MESA possesses anti-diarrheal property. The findings represent a rational explanation for its use in traditional medicine for the management of diarrhea management.
卢氏植物，传统上用于治疗痢疾和腹泻等止泻作用。本研究旨在证明该植物叶甲醇提取物在动物模型中的止泻活性。使用蓖麻油诱导的腹泻和硫酸镁诱导的腹泻模型评估止泻活性，而使用动物模型中的胃肠转运试验研究抗动力活性。在蓖麻油诱导的腹泻模型中，卢氏植物甲醇提取物（MESA）在100、200和400mg/kg剂量下，对蓖麻油诱导的大鼠腹泻粪便数量产生了统计学上显著的减少（P<0.001），并且硫酸镁诱导的腹泻模型也呈现相同情况。在胃肠转运试验中，胃排空时间显著延迟（P<0.001），胃肠道中炭末的推进在大鼠中也呈剂量依赖性。最近的研究表明MESA具有止泻特性。这些发现为其在传统医学中用于腹泻管理提供了合理的解释。
