Hirshman C A, McCullough R E, Cohen P J, Weil J V
Br J Anaesth. 1975 Sep;47(9):963-8. doi: 10.1093/bja/47.9.963.
The effect of an intramuscular injection of pentobarbitone 2 mg/kg on the hypoxic ventilatory drive was measured in 10 volunteers. Five subjects showed significant depression of the ventilatory response to hypoxia 30 min after administration. This depression persisted for 90 min. The other five subjects showed no change from control responses. The two groups appeared to differ in their levels of physical fitness as measured by differences in resting heart rate and maximal oxygen uptake.
对10名志愿者测量了肌肉注射2毫克/千克戊巴比妥对低氧通气驱动的影响。五名受试者在给药后30分钟对低氧的通气反应出现显著抑制。这种抑制持续了90分钟。另外五名受试者的反应与对照相比没有变化。通过静息心率和最大摄氧量的差异来衡量，两组受试者的身体素质水平似乎有所不同。
