Hong Tie, Jin Guang-Bi, Cho Shigefumi, Cyong Jong-Chol
Planta Med. 2002 Mar;68(3):268-71. doi: 10.1055/s-2002-23143.
The anti-inflammatory effect of three flavonoids from the root of Scutellaria baicalensis (baicalein, baicalin and wogonin) was evaluated in a murine model of acute experimental colitis induced by dextran sulfate sodium (DSS). Baicalein, but not baicalin or wogonin, given orally at 20 mg/kg for ten days, ameliorates all the considered inflammatory symptoms of the induced colitis, such as body weight loss, blood haemoglobin content, rectal bleeding and other histological and biochemical parameters. The effect of baicalein was similar to that of sulfasalazine, the reference drug given at 50 mg/kg.
在葡聚糖硫酸钠（DSS）诱导的急性实验性结肠炎小鼠模型中，评估了黄芩根中的三种黄酮类化合物（黄芩素、黄芩苷和汉黄芩素）的抗炎作用。黄芩素以20mg/kg的剂量口服给药十天，可改善诱导性结肠炎的所有炎症症状，如体重减轻、血血红蛋白含量、直肠出血以及其他组织学和生化参数，而黄芩苷和汉黄芩素则无此作用。黄芩素的效果与50mg/kg的参比药物柳氮磺胺吡啶相似。
