Department of Pharmacy, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Int J Mol Sci. 2023 Jan 19;24(3):1954. doi: 10.3390/ijms24031954.
Georgi (SBG), an herbal medicine with various biological activities, including anti-inflammatory, anticancer, antiviral, antibacterial, and antioxidant activities, is effective in treatment of colitis, hepatitis, pneumonia, respiratory infections, and allergic diseases. This herbal medicine consists of major active substances, such as baicalin, baicalein, wogonoside, and wogonin. Inflammatory bowel disease (IBD) comprises a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis being the main types. IBD can lead to serious complications, such as increased risk of colorectal cancer (CRC), one of the most common cancers worldwide. Currently, there is no cure for IBD, and its incidence has been increasing over the past few decades. This review comprehensively summarizes the efficacy of SBG in IBD and CRC and may serve as a reference for future research and development of drugs for IBD and cancer treatment.
圣草（SBG）是一种草药，具有多种生物活性，包括抗炎、抗癌、抗病毒、抗菌和抗氧化活性，可有效治疗结肠炎、肝炎、肺炎、呼吸道感染和过敏性疾病。这种草药由主要活性物质组成，如黄芩苷、黄芩素、汉黄芩苷和汉黄芩素。炎症性肠病（IBD）包括一组结肠和小肠的炎症性疾病，其中克罗恩病和溃疡性结肠炎是主要类型。IBD 可导致严重并发症，如结直肠癌（CRC）风险增加，CRC 是全球最常见的癌症之一。目前，IBD 无法治愈，其发病率在过去几十年中一直在增加。本综述全面总结了 SBG 在 IBD 和 CRC 中的疗效，可为未来 IBD 和癌症治疗药物的研究和开发提供参考。
